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排序方式: 共有6537条查询结果,搜索用时 62 毫秒
21.
Agata Ciurla Jolanta Szymaska Bartosz J. Pachno Anna Bogucka-Kocka 《International journal of molecular sciences》2021,22(2)
External apical root resorption (EARR) is one of the most serious complications associated with orthodontic treatment. The aim of the study was to analyze the relationships between selected single nucleotide polymorphisms (SNPs) in Interleukin 1 receptor antagonist (IL1RN), purinoreceptor P2X7 (P2RX7) and EARR in patients after orthodontic treatment. The study comprised 101 patients who underwent a complex orthodontic treatment with a combination of fixed appliances. Roots were measured based on orthopantomograms and lateral cephalometric radiographs taken before and at the end of the treatment using diagnostic software. Proportional measurements of selected teeth were made using the modified Linge and Linge methods. Based on the presence or absence of EARR, patients were divided into two groups: control group, 61 patients without EARR (with 0.90 ≤ rRCR ≤ 1.00), and EARR group, 40 patients with EARR (rRCR < 0.90). Root resorption in selected groups was also evaluated with the scores of Malmgren and Levander. SNP analysis was performed using the real-time polymerase chain reaction (PCR) method. The analysis indicated that a specific haplotype of P2RX7 (rs208294) and IL1RN (rs419598) modified the risk of EARR development (p < 0.05), with a Bonferroni correction. The analysis of the P2RX7 and IL1RN gene polymorphisms showed that the presence of SNPs of these genes may predispose individuals to EARR. These findings indicate that EARR is a complex condition influenced not only by environmental factors and needs further study on the genetic risk factors. 相似文献
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Sammy Drissi‐Amraoui Thibault E. Schmid Jimmy Lauberteaux Christophe Crvisy Olivier Basl Renata Marcia deFigueiredo Stphanie Halbert Hlne Grard Marc Mauduit Jean‐Marc Campagne 《Advanced Synthesis \u0026amp; Catalysis》2016,358(15):2519-2540
An efficient copper‐catalyzed enantioselective conjugate addition of dimethylzinc to unsaturated 2‐acyl‐N‐methylimidazoles has been achieved using a chiral bidentate hydroxyalkyl‐NHC ligand. The reactions proceed with excellent regioselectivity (1,4 vs. 1,6 and 1,8) in extended conjugated systems to afford the 1,4‐adducts in high enantioselectivities. This regioselectivity could be ascertained by DFT studies highlighting the crucial role of the imidazole ring. Thanks to the development of efficient protocols to regenerate the unsaturated 2‐acyl‐N‐methylimidazole moiety, an iterative process has been developed ultimately leading to 3,5,7 all‐syn or anti‐anti polydeoxypropionate stereodiads.
25.
Roberta Barbizan Mateus V. Castro Rui Seabra Ferreira Jr. Benedito Barraviera Alexandre L. R. Oliveira 《International journal of molecular sciences》2014,15(11):19535-19551
We recently proposed a new surgical approach to treat ventral root avulsion, resulting in motoneuron protection. The present work combined such a surgical approach with bone marrow mononuclear cells (MC) therapy. Therefore, MC were added to the site of reimplantation. Female Lewis rats (seven weeks old) were subjected to unilateral ventral root avulsion (VRA) at L4, L5 and L6 levels and divided into the following groups (n = 5 for each group): Avulsion, sealant reimplanted roots and sealant reimplanted roots plus MC. After four weeks and 12 weeks post-surgery, the lumbar intumescences were processed by transmission electron microscopy, to analyze synaptic inputs to the repaired α motoneurons. Also, the ipsi and contralateral sciatic nerves were processed for axon counting and morphometry. The ultrastructural results indicated a significant preservation of inhibitory pre-synaptic boutons in the groups repaired with sealant alone and associated with MC therapy. Moreover, the average number of axons was higher in treated groups when compared to avulsion only. Complementary to the fiber counting, the morphometric analysis of axonal diameter and “g” ratio demonstrated that root reimplantation improved the motor component recovery. In conclusion, the data herein demonstrate that root reimplantation at the lesion site may be considered a therapeutic approach, following proximal lesions in the interface of central nervous system (CNS) and peripheral nervous system (PNS), and that MC therapy does not further improve the regenerative recovery, up to 12 weeks post lesion. 相似文献
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Prof. Shanteri Singh Dr. Nitin S. Nandurkar Prof. Jon S. Thorson 《Chembiochem : a European journal of chemical biology》2014,15(10):1418-1421
Although bacterial iterative type I polyketide synthases are now known to participate in the biosynthesis of a small set of diverse natural products, the subsequent downstream modification of the resulting polyketide products is poorly understood. We report the functional characterization of the putative orsellinic acid C2‐O‐methyltransferase, which is involved in calicheamicin biosynthesis. This study suggests that C2‐O‐methylation precedes C3‐hydroxylation/methylation and C5‐iodination and requires a coenzyme A‐ or acyl carrier protein‐bound substrate. 相似文献
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APP改性沥青抗根卷材及其在屋顶花园防水工程中的应用 总被引:1,自引:0,他引:1
APP改性沥青抗根卷材不仅具有优良的防水性能,而且具有阻止植物根须长入和穿透卷材的特性,但不会影响植物根系的生长。此材料适用于不同气候条件下的屋顶花园防水工程中。 相似文献
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在已有车-桥耦合研究的基础上,推导了车-桥耦合系统的迭代解法.建立了车-桥系统模型,利用ANSYS软件分析单自由度质弹系统车辆模型在通过简支梁桥时桥梁的动力响应.用无量纲参数分析了在车-桥相互作用下,桥梁的位移响应与常力过桥时桥梁位移响应之间的差异.计算结果表明,迭代解法可方便求解车辆桥梁相互作用下,车-桥耦合系统的动力响应,其计算结果与相关文献结果较为一致. 相似文献
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针对水下边坡常规治理方法的不足,首次提出树根桩和土工膜袋混凝土联合治理技术.通过数值计算分析,及具体工程的实践,表明该技术具有良好的抗滑和防冲效果,值得推广应用. 相似文献